Respirateur pour rat, lapins, hamsters

Référence : VI-R407

Les respirateurs pour petits animaux Modèles VI-R407 sont de types volume contrôlé spécialement conçus pour les  rats  adultes, hamsters, lapins, sujets félins canins., avec un poids compris entre 200 Gr et 5 kg.


Les Respirateurs pour petits animaux Modèles VI-R407 sont de type Volumétrique à piston. Le volume est contrôlé. Il spécialement conçu pour les rats adultes, hamsters, lapins, sujets félins, canins. Avec un poids compris entre 200 grs et 5 kg.


Ces respirateurs sont mût par un moteur et contrôlés par un circuit de commande. Le flux d’air est généré par le mouvement d’un piston ( Pression positive) dont le mouvement est régulé. Le flux d’air est envoyé dans les poumons du sujet expérimental pour permettre une ventilation régulière.

L’écran LED affiche la fréquence respiratoire effective en temps réel une sortie  est disponible pour monitorer la pression d’expiration positive (PEP).

Fréquence et volume expiratoire sont ajustable pendant la ventilation.


C’est un respirateur robuste simple et silencieux.

Il est livré avec deux pistons qui couvrent les gammes de volume inspiratoire de 0,5 cc à 5 cc et 3-30 cc. Tubes silicones connecteur Trois voies Y, tube trachéale 14G, graisse et clé de maintenance.

Données techniques

Poids 7 kg
Dimensions 30 × 40 × 30 cm
Fréquence respi.

réglable de 18 à 150 cycles par minutes.

Volume inspiratoire

2 pistons:
0,5 cc-5 cc
3cc-30 cc

Poids sujets

à Partir de 200 Gr et jusqu'à 5 kg.

Contrôle fin d'expiration

via colonne à eau ou manomètre portable


220V-50 hz



Hydrogen Gas Attenuates Myocardial Ischemia Reperfusion Injury Independent of Postconditioning in Rats by Attenuating Endoplasmic Reticulum Stress-Induced Autophagy

GaoY et al.Logo Cellular Physiology and Biochemistry 2017

Background/Aims: To study the effect of inhaling hydrogen gas on myocardial ischemic/reperfusion(I/R) injury in rats. Methods: Seventy male Wistar albino rats were divided into five groups at random as the sham group (Sham). The I/R group (I/R), The ischemic postconditioning group (IPo), The I/R plus hydrogen group (IH2) and the ischemic postconditioning plus hydrogen group (IPoH2). The Sham group was without coronary occlusion. In I/R group, Ischemic/reperfusion injury was induced by coronary occlusion for 1 hour. Followed by 2 hours of reperfusion. In the IPo and IPoH2 group, four cycles of 1 min reperfusion/1 min ischemia was given at the end of 1 hour coronary occlusion.

MicroRNA‑20b‑5p promotes ventricular remodeling by targeting the TGF‑β/Smad signaling pathway in a rat model of ischemia‑reperfusion injury

Zhao‑Guang Liang et al.

Myocardial ischemic injury results from severe impairment of the coronary blood supply and may lead to metabolic and ultrastructural changes, thereby causing irreversible damage. MicroRNA (miR)‑20b‑5p has been demonstrated to be involved in malignancies of the breast, colorectum, stomach, blood and oropharynx. The present study aimed to investigate the effects of miR‑20b‑5p on ventricular remodeling following myocardial ischemia‑reperfusion (IR) injury in rats by targeting small mothers against decapentaplegic homolog 7 (Smad7) via the transforming growth factor‑β (TGF‑β)/Smad signaling pathway. A total of 70 adult male Sprague‑Dawley rats were divided into seven groups: Sham group, IR group, negative control group, miR‑20b‑5p mimics group, miR‑20b‑5p inhibitors group, small interfering RNA (siRNA)‑Smad7 group, and miR‑20b‑5p inhibitors + siRNA‑Smad7 group. Dual luciferase reporter gene assays were used to verify the association between miR‑20b‑5p and Smad7. Myocardial infarction size, myocardial collagen volume fraction and perivascular collagen area were detected separately using triphenyltetrazolium chloride and Masson’s staining.

Glibenclamide Prevents Water Diffusion Abnormality in the Brain After Cardiac Arrest in Rats

Kaibin Huang et al Neurocritical Care 2018

libenclamide (GBC) improves neurological outcome after cardiac arrest (CA) in rats. In this study, we sought to elucidate the mechanism responsible for the neuroprotective effects of GBC by using a high-field MRI system.

Evaluation of effect of atorvastatin on left ventricular systolic function in rats with myocardial infarction via 2D-STI technique

Yan Hua et al. Experimental and Therapeutic Medicine 2018

This report aims to evaluate the effect of atorvastatin (Ator) on left ventricular systolic function in myocardial infarction (MI) rats. Forty healthy adult Sprague-Dawley rats were randomly divided into four groups: Ator group, MI group, sham-operation group and normal group. The left anterior descending coronary arteries were ligated to establish the MI model; after modeling, the Ator group was treated with Ator for 4 consecutive weeks. The echocardiographic detection was performed; the left ventricular myocardial systolic peak velocities, strain and strain rates were analyzed using the 2D-STI technique. After 4 weeks, myocardial tissues were taken from all rats and received the pathological examination. Left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD) in Ator group and MI group were increased after operation, but left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were decreased; myocardial function were decreased significantly (p<0.05).

Prevention of cholesterol gallstone disease by schaftoside in lithogenic diet-induced C57BL/6 mouse model

Meijing Liu et al. European Journal of Pharmacology 2017

Schaftoside (SS) is a bioactive compound present in the Herba Desmodii Styracifolii (DS), a herb that has been used to treat cholelithiasis and urolithiasis in Chinese medicine. Whether SS inhibits cholesterol (Ch) gallstone formation has not been investigated. This study examined the effects of oral intake of SS on Ch gallstone formation in C57BL/6 mice fed a lithogenic diet. The rate of gallstone formation was recorded. Levels of Ch, triglycerides (TG) and bile salts (BS) were measured in the bile and serum. Liver histopathology was examined microscopically, and mRNA expression levels of key genes involved in cholesterol and bile metabolism were determined by qPCR. Mice fed SS were protected against gallstone formation, had increased biliary levels of BS, and reduced biliary Ch levels, resulting in a lower Ch saturation index (CSI). In addition, mice fed SS had lower serum TG and Ch levels, increased mRNA expression of liver X receptor α, ATP binding cassette transporter 5/8 (ABCG5/8), and ileal bile acid binding protein (IBABP) in the ileum, and of farnesoid X receptor and bile salt export protein (BSEP) in the liver and ileum. SS also protected against histologically determined liver damage. Overall, these data indicate that SS protects against Ch gallstone formation in mice, and that the effect is mediated by activation of ileal liver X receptor α and hepatic farnesoid X receptor.

The Effects and Mechanism of Atorvastatin on Pulmonary Hypertension Due to Left Heart Disease

Qing Wang et al. Plos one 2016

Pulmonary hypertension due to left heart disease (PH-LHD) is one of the most common forms of PH, termed group 2 PH. Atorvastatin exerts beneficial effects on the structural remodeling of the lung in ischemic heart failure. However, few studies have investigated the effects of atorvastatin on PH due to left heart failure induced by overload.

PET imaging of cardiomyocyte apoptosis in a rat myocardial infarction model

Hui Ma et al. Apoptosis 2018

Cardiomyocyte apoptosis has been observed in several cardiovascular diseases and contributes to the subsequent cardiac remodeling processes and progression to heart failure. Consequently, apoptosis imaging is helpful for noninvasively detecting the disease progression and providing treatment guidance. Here, we tested 18F-labeled 2-(5-fluoropentyl)-2-methyl-malonic acid (18F-ML-10) and 18F-labeled 2-(3-fluoropropyl)-2-methyl-malonic acid (18F-ML-8) for apoptosis imaging in rat models of myocardial infarction (MI) and compared them with 18F-fluorodeoxyglucose (18F-FDG). MI was induced in Sprague-Dawley rats by permanent left coronary artery ligation. Procedural success was confirmed by echocardiography and positron emission tomography (PET) imaging with 18F-FDG. In vivo PET imaging with 18F-ML-10 and 18F-ML-8 was performed in the MI models at different time points after operation. Terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assays and immunohistochemical analyses were used to evaluate myocardial apoptosis.

Epigallocatechin gallate attenuates mitochondrial DNA-induced inflammatory damage in the development of ventilator-induced lung injury

Chao-yiQin et al. Phytomedicine 2018

We aim to investigate the role of mitochondrial DNA (mtDNA), a novel endogenous pro-inflammatory cytokine, in the development of ventilator-induced lung injury (VILI). Moreover, the protective effect of epigallocatechin gallate (EGCG) on VILI through inhibiting local mtDNA release was examined.

Establishment of a precise novel brain trauma model in a large animal based on injury of the cerebral motor cortex

JipengJiang et al.Journal of Neuroscience Methods 2018